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Crop plants are att acked by a vast number of plant pathogens that caused various types of yield losses ranging from blemishes to complete crop losses. In some systems, plant pathogens are diffi cult to manage because their populations vary in time, space, and genotype. Chapters 1 to 9 addressed issues related to fungicide effi cacy on various crops and in various environments. Plant pathogens evolve, oft en overcoming the action of fungicides. The fi rst families of fungicides introduced prior to 1970 were mostly multi-sites fungal inhibitors most oft en used to protected plant from pathogen’s attack. Despite their widespread use, resistance to these compounds was rarely reported. However, following the introduction of single-site fungicides, resistance has become a major problem.